Detalhe da pesquisa
1.
Fatal Cytomegalovirus Infection in an Adult with Inherited NOS2 Deficiency.
N Engl J Med
; 382(5): 437-445, 2020 01 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31995689
2.
Potentiation of rifampin activity in a mouse model of tuberculosis by activation of host transcription factor EB.
PLoS Pathog
; 16(6): e1008567, 2020 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-32574211
3.
Evidence for dispensability of protein kinase R in host control of tuberculosis.
Eur J Immunol
; 48(4): 612-620, 2018 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-29436711
4.
E1 of α-ketoglutarate dehydrogenase defends Mycobacterium tuberculosis against glutamate anaplerosis and nitroxidative stress.
Proc Natl Acad Sci U S A
; 112(43): E5834-43, 2015 Oct 27.
Artigo
em Inglês
| MEDLINE | ID: mdl-26430237
5.
Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase.
Biochemistry
; 52(51): 9375-84, 2013 Dec 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-24251446
6.
Shape-Based Virtual Screening of a Billion-Compound Library Identifies Mycobacterial Lipoamide Dehydrogenase Inhibitors.
ACS Bio Med Chem Au
; 3(6): 507-515, 2023 Dec 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-38144256
7.
Identification of new inhibitors of protein kinase R guided by statistical modeling.
Bioorg Med Chem Lett
; 21(13): 4108-14, 2011 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-21632247
8.
Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions.
ACS Infect Dis
; 7(2): 435-444, 2021 02 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-33527832
9.
Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase .
Biochemistry
; 49(8): 1616-27, 2010 Mar 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-20078138
10.
Identification of a copper-binding metallothionein in pathogenic mycobacteria.
Nat Chem Biol
; 4(10): 609-16, 2008 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-18724363
11.
Comparison of transposon and deletion mutants in Mycobacterium tuberculosis: The case of rv1248c, encoding 2-hydroxy-3-oxoadipate synthase.
Tuberculosis (Edinb)
; 95(6): 689-694, 2015 Dec.
Artigo
em Inglês
| MEDLINE | ID: mdl-26547230
12.
Virulence of Mycobacterium tuberculosis depends on lipoamide dehydrogenase, a member of three multienzyme complexes.
Cell Host Microbe
; 9(1): 21-31, 2011 Jan 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-21238944
13.
Central carbon metabolism in Mycobacterium tuberculosis: an unexpected frontier.
Trends Microbiol
; 19(7): 307-14, 2011 Jul.
Artigo
em Inglês
| MEDLINE | ID: mdl-21561773
14.
A philosophy of anti-infectives as a guide in the search for new drugs for tuberculosis.
Tuberculosis (Edinb)
; 88 Suppl 1: S25-33, 2008 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-18762150
15.
Selective killing of nonreplicating mycobacteria.
Cell Host Microbe
; 3(3): 137-45, 2008 Mar 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-18329613
16.
Mycobacterium tuberculosis appears to lack alpha-ketoglutarate dehydrogenase and encodes pyruvate dehydrogenase in widely separated genes.
Mol Microbiol
; 57(3): 859-68, 2005 Aug.
Artigo
em Inglês
| MEDLINE | ID: mdl-16045627
17.
Variant tricarboxylic acid cycle in Mycobacterium tuberculosis: identification of alpha-ketoglutarate decarboxylase.
Proc Natl Acad Sci U S A
; 102(30): 10670-5, 2005 Jul 26.
Artigo
em Inglês
| MEDLINE | ID: mdl-16027371
18.
Crystal structure and functional analysis of lipoamide dehydrogenase from Mycobacterium tuberculosis.
J Biol Chem
; 280(40): 33977-83, 2005 Oct 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-16093239